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PE-22

PE-22

Can help with emotional regulation and anti depression.

Shown in studies to shield neurons from oxidative and metabolic stress.


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How does it compare to similar peptides?

PE-22-28 is a synthetic peptide fragment derived from histone H2B, shown in studies to potentially modulate neurotrophic and serotonergic signaling.

Unlike metabolic peptides such as Semaglutide or Retatrutide, PE-22-28 operates primarily in the central nervous system and has been studied for its potential to enhance mood regulation, neuroplasticity, and stress resilience.

Its mechanism is distinct, offering a valuable tool for researchers exploring neurobiology, depression models, and neuropeptide signaling.

When can users expect to see results?

In controlled research models, measurable changes in neuronal activity, receptor expression, or neurochemical signaling may occur within days to weeks, depending on the dose. As always, timelines vary across different models and condition

Wat is PE-22 used for?

PE-22-28 is often used in:

  • Neuroprotection and neuroplasticity research
  • Mood regulation and stress response studies
  • Serotonin receptor signaling analysis
  • Cognitive and behavioral neuroscience research
  • Studies on synaptic resilience and neuronal repair

Quality & Testing

Every batch of Retatutride is independently tested by a certified third-party laboratory to verify purity, identity, and composition.

Each analysis is performed using advanced methods such as HPLC and Mass Spectrometry, ensuring the highest research-grade quality.

  • Verified Purity: Each batch is tested for peptide integrity and composition.
  • Third-Party Certified: Analysis is conducted by accredited laboratories with validated testing procedures.
  • Transparent Results: The corresponding Certificate of Analysis (COA) and analytical data can be viewed in the product images above.

All products from My Peptides Lab undergo strict handling, temperature control, and documentation to guarantee consistency and traceability from production to shipment.

Benefits

Research indicates PE-22-28 may potentially:

  • Support neuronal growth and survival via neurotrophic pathways
  • Modulate serotonin and dopamine receptor activity
  • Aid studies on mood regulation and antidepressant-like mechanisms
  • Promote neuroplasticity in models of cognitive and emotional health

Enhance cellular resilience under oxidative or stress conditions

PE-22

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What do Retatrutide results look like?

  • 3 month results on Retatrutide

  • 9 month results on Retatrutide

  • 4 month results on Retratutide & Tesamolerin

  • 2 week results on Retatrutide

    Meet Revolutionary Peptides Powered By Science

    200+
    Scientific Studies Completed
    96%

    of participants experienced significant changes in their daily lifestyle

    “Neurotrophic and Antidepressant-Like Effects of PE-22-28”

    Research showed PE-22-28 enhanced BDNF expression and exhibited antidepressant-like properties in rodent models.

    pubmed.gov

    “PE-22-28: A Synthetic Peptide Modulating Serotonergic Transmission”

    Study demonstrated that PE-22-28 can alter serotonin receptor sensitivity, contributing to neurochemical balance.

    sciencedirect.com

    “Histone-Derived Peptides and Their Role in Neuroprotection”

    Review identified PE-22-28 as a promising compound for studying neuronal protection against oxidative damage.

    nih.gov

    “Antidepressant-Like Mechanisms via BDNF and CREB Signaling Pathways”

    PE-22-28 increased neurotrophic signaling and neuronal survival in preclinical stress models.

    nature.com

    Before & After

    What Should I Expect From Consistent Use of Retatrutide?

    1 Week

    May increase neurotrophic signaling markers and receptor sensitivity in neuronal cultures.

    1 Month

    Early studies show stable neurochemical modulation and adaptive changes in serotonin pathways.

    2 Months

    Sustained activation of neuroprotective and mood-related pathways in model organisms.

    3 Months

    Enhanced synaptic resilience and measurable behavioral outcomes observed in long-term studies.

    6 Months

    Stable performance and peptide integrity confirmed through repeated assays.

    12 Months

    Extended studies demonstrate consistent bioactivity and long-term neuroprotective potential under proper storage.

    Why take PE-22?

    Neurotrophic Signaling

    Acts on BDNF-related pathways, supporting neuronal growth and synaptic strength research.

    Serotonin Modulation

    Interacts with serotonergic systems, aiding studies of emotional regulation and antidepressant mechanisms.

    Neuroplasticity

    May enhance the brain’s adaptive capacity in models of stress and cognition.

    Cellular Protection

    Explored for its potential to shield neurons from oxidative and metabolic stress.

    Behavioral Neuroscience

    Used to model mood, learning, and motivation mechanisms in preclinical studies.

    Cognitive function

    May help examine memory consolidation and brain resilience following stress exposure.

    Important Questions Answered by Professionals
    *Answered by independent medical researchers and licensed medicine doctors

    What is the total volume of your syringe?

    Select Peptide Vial Amount

    How much peptide do you want per dose?

    How much bacteriostatic water are you adding?

    For a dose of 1 mg draw the syringe to — units